Cannabis and the Lung
Part 2 of a continuing series on cannabis and cannabinoids. This episode focuses on the effect of smoking cannabis joints on the lungs.
Citations:
1. Cannabis smoke, chemical analysis
Chem Res Toxicol. 2008 Feb;21(2):494-502.
"A comparison of mainstream and sidestream marijuana and tobacco cigarette smoke produced under two machine smoking conditions."
2. Cannabis smoke, genotoxicity
Chem Res Toxicol. 2009 Aug;22(8):1406-14.
"The genotoxicity of mainstream and sidestream marijuana and tobacco smoke condensates."
3. North Africa pooled lung cancer study
J Thorac Oncol. 2008 Dec;3(12):1398-403.
"Cannabis smoking and risk of lung cancer in men: a pooled analysis of three studies in Maghreb."
http://journals.lww.com/jto/pages/art...
4. New Zealand Cancer Registry case-control study
Eur Respir J. 2008 Feb;31(2):280-6.
Cannabis use and risk of lung cancer: a case-control study.
http://www.ncbi.nlm.nih.gov/pmc/artic...
5. The UCLA study
Cancer Epidemiol Biomarkers Prev. 2006 Oct;15(10):1829-34.
"Marijuana use and the risk of lung and upper aerodigestive tract cancers: results of a population-based case-control study."
http://cebp.aacrjournals.org/content/...
6. The pooled ILCC study
Int J Cancer. 2015 Feb 15;136(4):894-903.
"Cannabis smoking and lung cancer risk: Pooled analysis in the International Lung Cancer Consortium."
http://onlinelibrary.wiley.com/doi/10...
7. Bronchoalveolar lavage in tobacco and marijuana smokers with matched controls
Am Rev Respir Dis. 1987 Jun;135(6):1271-5.
"Differential examination of bronchoalveolar lavage cells in tobacco cigarette and marijuana smokers."
http://www.ncbi.nlm.nih.gov/pubmed/35...
Generally useful background reading:
8. Ann Am Thorac Soc. 2013 Jun;10(3):239-47.
"Effects of marijuana smoking on the lung."
http://www.ncbi.nlm.nih.gov/pubmed/23...
9. Monaldi Arch Chest Dis. 2005 Jun;63(2):93-100.
"Smoked marijuana as a cause of lung injury."
http://www.ncbi.nlm.nih.gov/pubmed/16...
10. J Clin Pharmacol. 2002 Nov;42(11 Suppl):71S-81S.
"Respiratory and immunologic consequences of marijuana smoking."
http://onlinelibrary.wiley.com/doi/10...
11. Eur Respir J. 2010 Jan;35(1):42-7.
"Effects of cannabis on lung function: a population-based cohort study."
http://www.ncbi.nlm.nih.gov/pmc/artic...
12. Thorax. 2007 Dec;62(12):1058-63. Epub 2007 Jul 31.
"Effects of cannabis on pulmonary structure, function and symptoms."
http://www.ncbi.nlm.nih.gov/pmc/artic...
13. Addiction. 2000 Nov;95(11):1669-77.
"The respiratory effects of cannabis dependence in young adults."
http://www.ncbi.nlm.nih.gov/pubmed/11...
14. Expert Rev Respir Med. 2011 Aug;5(4):537-46
"Effects of smoking cannabis on lung function."
http://www.ncbi.nlm.nih.gov/pubmed/21...
15. Curr Opin Pulm Med. 2014 Mar;20(2):173-9.
"Marijuana and lung diseases."
http://www.ncbi.nlm.nih.gov/pubmed/24...
16. Pharmacol Biochem Behav. 1991 Nov;40(3):629-36.
"Marijuana and tobacco smoke gas-phase cytotoxins."
17. Respirology. 2014 Jul;19(5):655-62.
"Cannabis smoking and respiratory health: consideration of the literature."
http://onlinelibrary.wiley.com/doi/10...
18. J Immunol. 2015 Jun 1;194(11):5211-22.
"Critical Role of Mast Cells and Peroxisome Proliferator-Activated Receptor γ in the Induction of Myeloid-Derived Suppressor Cells by Marijuana Cannabidiol In Vivo."
http://www.jimmunol.org/content/194/1...
19. Eur J Immunol. 2010 Dec;40(12):3358-71.
"Cannabinoid receptor activation leads to massive mobilization of myeloid-derived suppressor cells with potent immunosuppressive properties."
http://www.ncbi.nlm.nih.gov/pmc/artic...
20. Toxicology. 2013 Jun 7;308:60-73.
"A global toxicogenomic analysis investigating the mechanistic differences between tobacco and marijuana smoke condensates in vitro."
http://www.sciencedirect.com/science/...
