Scientists Discover the Holy Grail of Longevity? Blocking IL-11 To Reverse Aging & Extend Healthspan
Professor Stuart Cook talks about blocking Interleukin-11 reverses multiple hallmarks of aging. This therapy may have the similar effects of combination of rapamycin, metformin and senolytics. The IL-11/ERK/mTOR axis of senescence is a therapeutic target for extending mammalian healthspan.
https://www.nature.com/articles/s4158...
Inhibition of IL-11 signalling extends mammalian healthspan and lifespan
https://www.ncbi.nlm.nih.gov/pmc/arti...
IL11 stimulates ERK/P90RSK to inhibit LKB1/AMPK and activate mTOR initiating a mesenchymal program in stromal, epithelial, and cancer cells
https://www.ncbi.nlm.nih.gov/pmc/arti...
Understanding interleukin 11 as a disease gene and therapeutic target
https://neurosciencenews.com/inflamma...
Blocking Inflammation Protein Extends Lifespan
https://www.telegraph.co.uk/news/2024...
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