Defeating the new version of Uumuu on Radiant difficulty in the Hall of Gods for the Godmaster DLC. Radiant difficulty increases the boss health and some minor tweaks, plus you die in one hit.
It takes some getting used to hitting the squids to make Uumuu vulnerable. I suggest staying in the top corners to bait Uumuu to the top of the screen so that you have as much time as possible to line up shots when squids spawn. You will need to move from the corner if the lightning patches are following you. Do not attack squids when they are in a platform or on Uumuu with your nail or you will blow yourself up (magic is fine). Don't get greedy and you should kill him.
Above all, remember Uumuu's advice: ...DO NOT DESPAIR...
Good luck!